Synthetic studies connected with the preparation of h+/k+-ATPase inhibitors rabeprazole and lansoprazole

Synthetic studies connected with the preparation of h+/k+-ATPase inhibitors rabeprazole and lansoprazole

Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2‐[(4‐nitro‐3‐methylpyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole and 2‐[(4‐chloro‐3‐methyl‐pyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole, were prepared in several ways....

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Veröffentlicht in:Journal of heterocyclic chemistry 2006-11, Vol.43 (6), p.1447-1453
Hauptverfasser: Rédl, Stanislav, Klecén, Ondřej, Havlíček, Jaroslav
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2‐[(4‐nitro‐3‐methylpyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole and 2‐[(4‐chloro‐3‐methyl‐pyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole, were prepared in several ways.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570430606