Stereoselective multicomponent synthesis of [3-(5-substituted 2-methoxyphenyl)-5-aryl-2-phenyltetrahydro-4-isoxazolyl](2-thienyl)methanones via 1,3-dipolar cycloaddition

Three‐component stereoselective synthesis of a set of new tetra substituted isoxazolidines from 5‐substi‐tuted 2‐methoxybenzaldehydes, N‐phenylhydroxylamine and 1‐(2‐thienyl)‐3‐arylprop‐2‐en‐1‐ones has been achieved. The effect of microwave irradiation on the reaction under solvent‐free conditions has also been investigated. The stereochemistry of the final products has been confirmed by NMR and single crystal X‐ray analysis.