Regioselective synthesis of 3,3-diethyl-4-(methylene)-1-quinol-2-ones by an intramolecular microwave assisted heck reaction

Regioselective synthesis of 3,3-diethyl-4-(methylene)-1-quinol-2-ones by an intramolecular microwave assisted heck reaction

A protocol for the intramolecular Heck cyclization to afford 3,3‐diethyl‐4‐(methylene)‐1‐quinol‐2‐ones is described. We observed that the use of microwave irradiation increased the efficiency of the reaction. Several examples are presented which show the versatility of the reaction.

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Veröffentlicht in:Journal of heterocyclic chemistry 2005-03, Vol.42 (2), p.327-331
Hauptverfasser: Smalley Jr, Terrence L., Mills, Wendy Y.
Format: Artikel
Sprache:eng
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Zusammenfassung:A protocol for the intramolecular Heck cyclization to afford 3,3‐diethyl‐4‐(methylene)‐1‐quinol‐2‐ones is described. We observed that the use of microwave irradiation increased the efficiency of the reaction. Several examples are presented which show the versatility of the reaction.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570420225