Synthesis, NMR spectra and X-ray data of chloro and dichloro derivatives of 3-hydroxy-2-phenylquinolin-4(1H)-ones and their cytostatic activity

As known, some derivatives of quinolin‐4(1H)‐one possess interesting biological properties. The biological and cytostactic activity of 2‐substituted 3‐hydroxyquinolin‐4(1H)‐ones has not been reported yet. In this paper the synthesis of a series of chloro and dichloro 2‐phenyl‐3‐hydroxyquinolin‐4(1H)‐ones and their characterization by NMR spectra and X‐ray data is described. Their cytostatic properties have been evaluated and the results are reported.