Preparation of substituted 1,2‐Dihydro‐3 H ‐pyrazol‐3‐ones from polylithiated 2′‐phenylphenylacetohydrazides and aromatic esters

Preparation of substituted 1,2‐Dihydro‐3 H ‐pyrazol‐3‐ones from polylithiated 2′‐phenylphenylacetohydrazides and aromatic esters

Several 2′‐phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C ‐acylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5‐trisubstituted, 1,2‐dihy...

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Veröffentlicht in:Journal of heterocyclic chemistry 2001-05, Vol.38 (3), p.695-701
Hauptverfasser: Downs, Jennifer R., Pastine, Stefan J., Townsend, Jessica D., Greer, Heather A., Kelley, Wayne, Schady, Deborah A., Mcconaughy, Teresa Lentz, Metz, Clyde R., Beam, Charles F., Almquist, Catharine D., Pennington, William T., Walsch, Rosa D. Bailey
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Sprache:eng
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Zusammenfassung:Several 2′‐phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C ‐acylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5‐trisubstituted, 1,2‐dihydro‐3 H ‐pyrazol‐3‐ones.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570380326