Synthesis of five nevirapine metabolites

Synthesis of five nevirapine metabolites

Nevirapine (1) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the...

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Veröffentlicht in:Journal of heterocyclic chemistry 2000-03, Vol.37 (2), p.229-239
Hauptverfasser: Grozinger, Karl G., Byrne, Denis P., Nummy, Laurence J., Ridges, Michael D., Salvagno, Annette
Format: Artikel
Sprache:eng
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Zusammenfassung:Nevirapine (1) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570370203