Synthesis and binding properties of 2 H ‐1‐benzopyran‐2 one fluorophore‐linked calcium channel antagonist nifedipine (1,4‐dihydropyridine) analogs

Synthesis and binding properties of 2 H ‐1‐benzopyran‐2 one fluorophore‐linked calcium channel antagonist nifedipine (1,4‐dihydropyridine) analogs

Nifedipine analogs I, II and III with the 2 H ‐1‐benzopyran‐2‐one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (I...

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Veröffentlicht in:Journal of heterocyclic chemistry 1997-01, Vol.34 (1), p.301-304
Hauptverfasser: Padmanabhan, Seetharamaiyer, Peri, Ravikumar, Rutledge, Aleta, Triggle, David J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Nifedipine analogs I, II and III with the 2 H ‐1‐benzopyran‐2‐one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570340146