Synthesis of pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene method

Synthesis of pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene method

A highly convenient method for the synthesis of 2‐substituted pyrrole derivatives 7a‐c from pyrrole using phosgene was developed. Successively, 7‐methyl‐6,7‐dihydro‐1H,5H‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1a and 6,7‐dihydro‐1H,5H‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1b (aldisin) were synthesized by phospho...

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Veröffentlicht in:Journal of heterocyclic chemistry 1997-01, Vol.34 (1), p.87-91
Hauptverfasser: Cho, Hidetsura, Matsuki, Shinsuke, Mizuno, Akira, Annoura, Hirokazu, Tatsuoka, Toshio
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly convenient method for the synthesis of 2‐substituted pyrrole derivatives 7a‐c from pyrrole using phosgene was developed. Successively, 7‐methyl‐6,7‐dihydro‐1H,5H‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1a and 6,7‐dihydro‐1H,5H‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1b (aldisin) were synthesized by phosphorus pentoxide/methanesulfonate and polyphosphoric acid cyclization.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570340115