Synthesis of (±)-trans-hexahydropyrrolo[3,4-d]oxazol-2-one and its derivatives by using N-(tert-butyloxycarbonyl)-3-pyrroline as precursor

Synthetic method for the preparation of (±)‐trans‐hexahydropyrrolo[3,4‐d]oxazol‐2‐one and its derivatives has been developed. By one route, an efficient preparation of these fused heterobicyclic moieties could be achieved, which are prepared by using N‐(tert‐butyloxycarbonyl)‐3‐pyrroline as precursor. These fused heterobicyclic systems could be useful to develop a series of 2‐oxazolidinone analogues. J. Heterocyclic Chem., (2010).