Synthesis, complexation, and biological activity studies of 4-aminomethyl-7,8-dihydroxy coumarines and their crown ether derivatives

The article focuses synthesis of novel 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by 1H NMR, 13C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca2+, Mg2+, Fe2+, Zn2+, Ni2+, Cd2+, Co2+, and Mn2+ ions at 25°C ± 0.1 with the 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma‐Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity. J. Heterocyclic Chem., (2010).