Synthesis of indolo[2,1‐ a ]isoquinolines by CF 3 COOH ‐induced cyclization
Indolo[2,1‐ a ]isoquinoline alkaloids and related compounds have been known to have interesting biological activities, such as antileukemic and antitumor activities. We found that 1‐(3,4‐dimethoxyphenethyl)indole gave 2,3‐dimethoxyindolo[2,1‐ a ]isoquinoline and 1‐(3,4‐dimethoxyphenylacetyl)indole g...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2020-10, Vol.57 (10), p.3703-3708 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Indolo[2,1‐
a
]isoquinoline alkaloids and related compounds have been known to have interesting biological activities, such as antileukemic and antitumor activities. We found that 1‐(3,4‐dimethoxyphenethyl)indole gave 2,3‐dimethoxyindolo[2,1‐
a
]isoquinoline and 1‐(3,4‐dimethoxyphenylacetyl)indole gave 2,3‐dimethoxy‐6‐oxoindolo[2,1‐
a
]isoquinoline, respectively, by an intramolecular cyclization carried out in boiling trifluoroacetic acid. |
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| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.4078 |