Synthesis and in vitro evaluation of novel tetralin‐pyrazolo[3,4‐b]pyridine hybrids as potential anticancer agents
New hybrids of tetralin‐pyrazolo[3,4‐b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines...
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Veröffentlicht in: | Journal of heterocyclic chemistry 2020-01, Vol.57 (1), p.182-196 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | New hybrids of tetralin‐pyrazolo[3,4‐b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF‐7). Most of the examined derivatives showed promising anticancer activity. |
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ISSN: | 0022-152X 1943-5193 |
DOI: | 10.1002/jhet.3764 |