Synthesis of 6‐Oxo‐1,2,3,4,6,7,12,12 b ‐octahydroindolo[2,3‐ a ]quinolizine

Synthesis of 6‐Oxo‐1,2,3,4,6,7,12,12 b ‐octahydroindolo[2,3‐ a ]quinolizine

An efficient synthesis of 6‐oxo‐1,2,3,4,5,7,12,12 b ‐octahydroindolo[2,3‐ α ]quinolizine from 2‐acetylpyridine and phenylhydrazine is described. This derivative of the natural alkaloid desbromoarborescidine A is an important entry point to the sarpagine‐vobasine family of plant alkaloids....

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Veröffentlicht in:Journal of heterocyclic chemistry 2018-04, Vol.55 (4), p.1048-1052
Hauptverfasser: Tompkins, David C., Reilly, Laurence W., Nelson, Randall B., Dolby, Lloyd J., Gribble, Gordon W.
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient synthesis of 6‐oxo‐1,2,3,4,5,7,12,12 b ‐octahydroindolo[2,3‐ α ]quinolizine from 2‐acetylpyridine and phenylhydrazine is described. This derivative of the natural alkaloid desbromoarborescidine A is an important entry point to the sarpagine‐vobasine family of plant alkaloids.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3130