Synthesis and Antimicrobial Screening of Some Novel 2‐(5‐(4‐(1 H ‐Benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1 H ‐pyrazol‐3‐yl)phenols Incorporated by Triazole Moiety

A novel series of 2‐(5‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1 H ‐pyrazol‐3‐yl)phenols derivative has been synthesized from ( E )‐3‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐ones in ethanol and hydrazine hydrate under reflux condition. The syn...

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Veröffentlicht in:Journal of heterocyclic chemistry 2014-03, Vol.51 (2), p.513-517
Hauptverfasser: Shaikh, Mohammad U., Jadhav, Ganesh R., Kale, Rajesh P., Chate, Asha V., Nagargoje, Deepak R., Gill, Charansingh H.
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Sprache:eng
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Zusammenfassung:A novel series of 2‐(5‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1 H ‐pyrazol‐3‐yl)phenols derivative has been synthesized from ( E )‐3‐(4‐(1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐ones in ethanol and hydrazine hydrate under reflux condition. The synthesized compounds were screened for antibacterial activity against Gram‐positive bacteria viz Staphylococcus aureus and Bacillus subtilis and Gram‐negative bacteria viz Escherichia coli and Salmonella typhi , respectively. Some of the tested compounds showed significant antimicrobial activity. IR, 1 H NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1646