A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs

A general synthetic approach has been developed for heterocyclic prostaglandins (PGF 2α type) starting from the key intermediate ( 6 ). (±) 6 was obtained from (±) ‐Corey lactone. The key intermediate (±) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and...

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Veröffentlicht in:Journal of heterocyclic chemistry 2014-07, Vol.51 (4), p.1086-1093
Hauptverfasser: M., Shankar, H., Rama Mohan, U., Viplava Prasad, M., Harikrishna, M. P., Pareswar Rao, A., Ravindra
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container_end_page 1093
container_issue 4
container_start_page 1086
container_title Journal of heterocyclic chemistry
container_volume 51
creator M., Shankar
H., Rama Mohan
U., Viplava Prasad
M., Harikrishna
M. P., Pareswar Rao
A., Ravindra
description A general synthetic approach has been developed for heterocyclic prostaglandins (PGF 2α type) starting from the key intermediate ( 6 ). (±) 6 was obtained from (±) ‐Corey lactone. The key intermediate (±) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.
doi_str_mv 10.1002/jhet.1622
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title A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs
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