A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs
A general synthetic approach has been developed for heterocyclic prostaglandins (PGF 2α type) starting from the key intermediate ( 6 ). (±) 6 was obtained from (±) ‐Corey lactone. The key intermediate (±) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and...
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Veröffentlicht in: | Journal of heterocyclic chemistry 2014-07, Vol.51 (4), p.1086-1093 |
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container_issue | 4 |
container_start_page | 1086 |
container_title | Journal of heterocyclic chemistry |
container_volume | 51 |
creator | M., Shankar H., Rama Mohan U., Viplava Prasad M., Harikrishna M. P., Pareswar Rao A., Ravindra |
description | A general synthetic approach has been developed for heterocyclic prostaglandins (PGF
2α
type) starting from the key intermediate (
6
). (±)
6
was obtained from (±) ‐Corey lactone. The key intermediate (±)
6
was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations. |
doi_str_mv | 10.1002/jhet.1622 |
format | Article |
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2α
type) starting from the key intermediate (
6
). (±)
6
was obtained from (±) ‐Corey lactone. The key intermediate (±)
6
was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.</description><identifier>ISSN: 0022-152X</identifier><identifier>EISSN: 1943-5193</identifier><identifier>DOI: 10.1002/jhet.1622</identifier><language>eng</language><ispartof>Journal of heterocyclic chemistry, 2014-07, Vol.51 (4), p.1086-1093</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c229t-ec5a6c987e63774b613445055f4fc2780aa4252b788bb86cf55a56a9c1f9b6433</citedby><cites>FETCH-LOGICAL-c229t-ec5a6c987e63774b613445055f4fc2780aa4252b788bb86cf55a56a9c1f9b6433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>M., Shankar</creatorcontrib><creatorcontrib>H., Rama Mohan</creatorcontrib><creatorcontrib>U., Viplava Prasad</creatorcontrib><creatorcontrib>M., Harikrishna</creatorcontrib><creatorcontrib>M. P., Pareswar Rao</creatorcontrib><creatorcontrib>A., Ravindra</creatorcontrib><title>A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs</title><title>Journal of heterocyclic chemistry</title><description>A general synthetic approach has been developed for heterocyclic prostaglandins (PGF
2α
type) starting from the key intermediate (
6
). (±)
6
was obtained from (±) ‐Corey lactone. The key intermediate (±)
6
was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.</description><issn>0022-152X</issn><issn>1943-5193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNotkM1KxDAYRYMoWEcXvsG3ddGx-W2zLIN1hEFlVHBX0pjMdIiNJFHoY_kiPpMturpcLlwOB6FLXCxxUZDrw96kJRaEHKEMS0ZzjiU9Rtm0kRxz8nqKzmI8TBXTsszQtoZG6d4Z2PrPZMD6AGlv4Gkcpoh9BG_h3n8ZB2uTTPB61K7X8Bh8TGrn1PDWD9AA-fmGelDO7-I5OrHKRXPxnwv00tw8r9b55uH2blVvck2ITLnRXAktq9KIiYR1AlPGeMG5ZVaTsiqUYoSTrqyqrquEtpwrLpTU2MpOMEoX6OrvV08sMRjbfoT-XYWxxUU7y2hnGe0sg_4C6l1SZQ</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>M., Shankar</creator><creator>H., Rama Mohan</creator><creator>U., Viplava Prasad</creator><creator>M., Harikrishna</creator><creator>M. P., Pareswar Rao</creator><creator>A., Ravindra</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140701</creationdate><title>A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs</title><author>M., Shankar ; H., Rama Mohan ; U., Viplava Prasad ; M., Harikrishna ; M. P., Pareswar Rao ; A., Ravindra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-ec5a6c987e63774b613445055f4fc2780aa4252b788bb86cf55a56a9c1f9b6433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>M., Shankar</creatorcontrib><creatorcontrib>H., Rama Mohan</creatorcontrib><creatorcontrib>U., Viplava Prasad</creatorcontrib><creatorcontrib>M., Harikrishna</creatorcontrib><creatorcontrib>M. P., Pareswar Rao</creatorcontrib><creatorcontrib>A., Ravindra</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of heterocyclic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>M., Shankar</au><au>H., Rama Mohan</au><au>U., Viplava Prasad</au><au>M., Harikrishna</au><au>M. P., Pareswar Rao</au><au>A., Ravindra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs</atitle><jtitle>Journal of heterocyclic chemistry</jtitle><date>2014-07-01</date><risdate>2014</risdate><volume>51</volume><issue>4</issue><spage>1086</spage><epage>1093</epage><pages>1086-1093</pages><issn>0022-152X</issn><eissn>1943-5193</eissn><abstract>A general synthetic approach has been developed for heterocyclic prostaglandins (PGF
2α
type) starting from the key intermediate (
6
). (±)
6
was obtained from (±) ‐Corey lactone. The key intermediate (±)
6
was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω‐side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.</abstract><doi>10.1002/jhet.1622</doi><tpages>8</tpages></addata></record> |
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identifier | ISSN: 0022-152X |
ispartof | Journal of heterocyclic chemistry, 2014-07, Vol.51 (4), p.1086-1093 |
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language | eng |
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title | A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F 2α Analogs |
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