2-Cyanoacetamide in the Synthesis of Heterocyclic Compounds: Synthesis of New Polysubstituted Pyrazole, Pyridine and Pyrimidine Derivatives

2-Cyanoacetamide in the Synthesis of Heterocyclic Compounds: Synthesis of New Polysubstituted Pyrazole, Pyridine and Pyrimidine Derivatives

Phenylmethylenecyanoacetamide (1) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one‐pot reaction step. Hydrazine hydrate (2a,b), cyanoacetamide (6a), cyanothioacetamide (6b), cyanoacetic acid hydrazide (6c), thiosemicarbazide (10), urea (14a), t...

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Veröffentlicht in:Journal of the Chinese Chemical Society (Taipei) 2004-08, Vol.51 (4), p.779-784
Hauptverfasser: El-Rady, Eman A., Khalil, Mohamed A.
Format: Artikel
Sprache:eng
Schlagworte:
Phenylmethylenecyanoacetamide
Pyrazole
Pyridine and pyrimidine
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Zusammenfassung:Phenylmethylenecyanoacetamide (1) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one‐pot reaction step. Hydrazine hydrate (2a,b), cyanoacetamide (6a), cyanothioacetamide (6b), cyanoacetic acid hydrazide (6c), thiosemicarbazide (10), urea (14a), thiourea (14b) and 2‐phenylenediamine (24) were selected as amine nucleophile reagents.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.200400118