CtBP2 contributes to malignant development of human esophageal squamous cell carcinoma by regulation of p16 INK4A

C‐terminal binding protein‐2 (CtBP2), as a transcriptional co‐repressor, has been shown to mediate the repression of p16 INK4A , a tumor suppressor gene product, in primary human cells. Here we aimed to investigate how the correlation between CtBP2 and p16 INK4A influenced the development of esophageal squamous cell carcinoma (ESCC). Immunohistochemistry of ESCC tissue sections indicated that the CtBP2 and p16 INK4A expressions were inversely correlated to each other with a linear regression coefficient of −0.747 ( P