Iron depletion before HCV antiviral therapy: A pilot, randomized, controlled trial

It is not known whether iron depletion before pegylated IFN or combination treatment improves sustained virological response (SVR) rate in patients with chronic hepatitis C, despite its use in clinical practice in this setting. We aimed to investigate whether blood letting improves the efficacy (SVR...

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Veröffentlicht in:	Journal of clinical apheresis 2009, Vol.24 (5), p.190-196
Hauptverfasser:	Gentile, Ivan, Viola, Chiara, Paesano, Luigi, D'Onofrio, Marcello, D'Agostino, Elio, Cerini, Raimondo, Borrelli, Francesco, Piazza, Marcello, Borgia, Guglielmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - administration & dosage Antiviral Agents - adverse effects blood letting Female ferritin Ferritins - blood Hepatitis C, Chronic - blood Hepatitis C, Chronic - therapy Humans Interferon-alpha - administration & dosage Interferon-alpha - adverse effects iron Iron - blood Male Middle Aged pegylated-interferon Phlebotomy Pilot Projects Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Recombinant Proteins ribavirin Ribavirin - administration & dosage Ribavirin - adverse effects Transferrin - analysis
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Zusammenfassung:	It is not known whether iron depletion before pegylated IFN or combination treatment improves sustained virological response (SVR) rate in patients with chronic hepatitis C, despite its use in clinical practice in this setting. We aimed to investigate whether blood letting improves the efficacy (SVR) and tolerability of PEG‐IFNα2b + Ribavirin in chronic hepatitis C patients. Patients with chronic hepatitis C and ferritin >100 ng/mL were randomized to: (1) repeated phlebotomies to obtain a ferritin level
ISSN:	0733-2459 1098-1101
DOI:	10.1002/jca.20210