Autoionization reaction of phosgene (OCC12) studied by electron paramagnetic resonance/spin trapping techniques

Autoionization reaction of phosgene (OCC12) studied by electron paramagnetic resonance/spin trapping techniques

The reaction of phosgene with ni‐trone spin traps was investigated using electron paramagnetic resonance (EPR)/spin trapping techniques. Evidence for the intermediacy of a carba‐moyl monochloride intermediate was obtained. Isotopic substitution of 13C‐phosgene was employed to verify the hyperfine co...

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Veröffentlicht in:Journal of biochemical toxicology 1993-06, Vol.8 (2), p.107-110
Hauptverfasser: Arroyo, Carmen M., Feliciano, Felix, Kolb, Dana L., Keeler, Jill R., Millette, Susan R., Stotts, Richard R.
Format: Artikel
Sprache:eng
Schlagworte:
Carba-moyl Monochloride Radical
Electron Spin Resonance Spectroscopy - methods
EPR
Free Radicals
Nitrogen Oxides - chemistry
Phosgene
Phosgene - chemistry
Spin Labels
Spin Trapping
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Zusammenfassung:The reaction of phosgene with ni‐trone spin traps was investigated using electron paramagnetic resonance (EPR)/spin trapping techniques. Evidence for the intermediacy of a carba‐moyl monochloride intermediate was obtained. Isotopic substitution of 13C‐phosgene was employed to verify the hyperfine coupling constant assignments. The implications of these observations on pulmonary damage caused by inhalation of phosgene are mentioned.
ISSN:0887-2082
1522-7146
DOI:10.1002/jbt.2570080208