Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces
Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biologic...
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Veröffentlicht in: | Journal of biomedical materials research 2004-08, Vol.70A (2), p.186-193 |
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description | Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biological factors that interact in the context of a hemodynamic environment. We sought to investigate the role of local environmental variations on determining indices of biocompatibility. Using a recently described in vitro flow apparatus, we separately studied the platelet and coagulative component responses to stainless steel endovascular stents with and without gold coating. When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 186–193, 2004 |
doi_str_mv | 10.1002/jbm.a.30023 |
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Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biological factors that interact in the context of a hemodynamic environment. We sought to investigate the role of local environmental variations on determining indices of biocompatibility. Using a recently described in vitro flow apparatus, we separately studied the platelet and coagulative component responses to stainless steel endovascular stents with and without gold coating. When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 186–193, 2004</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.30023</identifier><identifier>PMID: 15227663</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>biocompatibility ; Biocompatible Materials - adverse effects ; Blood Coagulation ; Blood Vessels - injuries ; environment ; flow ; Gold ; Hemodynamics ; Humans ; In Vitro Techniques ; Materials Testing ; Microscopy, Electron, Scanning ; Platelet Activation ; Stainless Steel ; stent ; Stents - adverse effects ; Surface Properties ; thrombosis ; Thrombosis - etiology ; Vascular Surgical Procedures - adverse effects</subject><ispartof>Journal of biomedical materials research, 2004-08, Vol.70A (2), p.186-193</ispartof><rights>Copyright © 2004 Wiley Periodicals, Inc.</rights><rights>Copyright 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 186-193, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4623-44c3739fdd0074f00047d0195548b373dd94c20177116965bb49cb65f0a17353</citedby><cites>FETCH-LOGICAL-c4623-44c3739fdd0074f00047d0195548b373dd94c20177116965bb49cb65f0a17353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.30023$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.30023$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15227663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolandaivelu, Kumaran</creatorcontrib><creatorcontrib>Edelman, Elazer R.</creatorcontrib><title>Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biological factors that interact in the context of a hemodynamic environment. We sought to investigate the role of local environmental variations on determining indices of biocompatibility. Using a recently described in vitro flow apparatus, we separately studied the platelet and coagulative component responses to stainless steel endovascular stents with and without gold coating. When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 186–193, 2004</description><subject>biocompatibility</subject><subject>Biocompatible Materials - adverse effects</subject><subject>Blood Coagulation</subject><subject>Blood Vessels - injuries</subject><subject>environment</subject><subject>flow</subject><subject>Gold</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Platelet Activation</subject><subject>Stainless Steel</subject><subject>stent</subject><subject>Stents - adverse effects</subject><subject>Surface Properties</subject><subject>thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Vascular Surgical Procedures - adverse effects</subject><issn>1549-3296</issn><issn>0021-9304</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9PFDEAhRsjEURP3E1PXsws_d0dbwiIENDLJhouTaftmGKnXdqZhT35r9t1V7h56kv6fa_pA-AIoxlGiBzfdcNMz2iN9AU4wJyThrWCv9xk1jaUtGIfvC7lrhICcfIK7GNOiBSCHoDf53Hlc4qDi6MO0Mc-TC4aV2CK0EWbVrqYKegMy1gRuAx6dMGNMDttRr_y4_ojPIlVhDXnBE0aljr7UvXUV0n7GFwpG90FqKOFP1OwsEy51_WZN2Cv16G4t7vzECw-ny9OvzTX3y4uT0-uG8MEoQ1jhkra9tYiJFmPEGLSItxyzuZdvbG2ZYYgLCXGon6-61hrOsF7pLGknB6C99vaZU73kyujGnwxLgQdXZqKIvO6Bxcb8MMWNDmVkl2vltkPOq8VRmozt6pzK63-zl3pd7vaqRucfWZ3-1YAb4EHH9z6f13q6tPNv9Jm6_i62eOTo_MvJSSVXH3_eqEIXZzNMfmhbukfbd6bHw</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Kolandaivelu, Kumaran</creator><creator>Edelman, Elazer R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20040801</creationdate><title>Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces</title><author>Kolandaivelu, Kumaran ; Edelman, Elazer R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4623-44c3739fdd0074f00047d0195548b373dd94c20177116965bb49cb65f0a17353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>biocompatibility</topic><topic>Biocompatible Materials - adverse effects</topic><topic>Blood Coagulation</topic><topic>Blood Vessels - injuries</topic><topic>environment</topic><topic>flow</topic><topic>Gold</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Platelet Activation</topic><topic>Stainless Steel</topic><topic>stent</topic><topic>Stents - adverse effects</topic><topic>Surface Properties</topic><topic>thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Vascular Surgical Procedures - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolandaivelu, Kumaran</creatorcontrib><creatorcontrib>Edelman, Elazer R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolandaivelu, Kumaran</au><au>Edelman, Elazer R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. 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When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 186–193, 2004</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15227663</pmid><doi>10.1002/jbm.a.30023</doi><tpages>8</tpages></addata></record> |
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subjects | biocompatibility Biocompatible Materials - adverse effects Blood Coagulation Blood Vessels - injuries environment flow Gold Hemodynamics Humans In Vitro Techniques Materials Testing Microscopy, Electron, Scanning Platelet Activation Stainless Steel stent Stents - adverse effects Surface Properties thrombosis Thrombosis - etiology Vascular Surgical Procedures - adverse effects |
title | Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces |
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