Biocompatibility testing of polymers: In vivo implantation studies

Biocompatibility testing of polymers: In vivo implantation studies

An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The method is reproducible and reliable. It is designed to provide uniform test crit...

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Veröffentlicht in:Journal of biomedical materials research 1978-03, Vol.12 (2), p.219-232
Hauptverfasser: Gourlay, Stuart J., Rice, Robert M., Hegyeli, Andrew F., Wade, Clarence W. R., Dillon, James G., Jaffe, Howard, Kulkarni, R. K.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biocompatible Materials - toxicity
Drug Evaluation, Preclinical
Male
Methods
Polymers - toxicity
Rats
Skin Tests
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Zusammenfassung:An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The method is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.820120207