Comparative effects of various lead salts on delayed hypersensitivity in mice
Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead ca...
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| Veröffentlicht in: | Journal of applied toxicology 1984-10, Vol.4 (5), p.265-266 |
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| container_end_page | 266 |
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| container_issue | 5 |
| container_start_page | 265 |
| container_title | Journal of applied toxicology |
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| creator | Descotes, Jacques Evreux, Jean Claude Laschi-Locquerie, Alda Tachon, Pierre |
| description | Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell‐mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present. |
| doi_str_mv | 10.1002/jat.2550040511 |
| format | Article |
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Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell‐mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550040511</identifier><identifier>PMID: 6512164</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Carbonates - toxicity ; cell-mediated immunity ; Chemical and industrial products toxicology. Toxic occupational diseases ; Female ; Hypersensitivity, Delayed ; Immunity, Cellular - drug effects ; immunotoxicity ; Lead - toxicity ; lead salts ; Male ; Medical sciences ; Metals and various inorganic compounds ; Mice ; Mice, Inbred BALB C ; Nitrates - toxicity ; Organometallic Compounds ; Toxicology</subject><ispartof>Journal of applied toxicology, 1984-10, Vol.4 (5), p.265-266</ispartof><rights>Copyright © 1984 John Wiley & Sons, Ltd.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4071-c99f6fba276960e4715cca79a6ecbb1b2b369cb70c3e76beaa3ec57000062a6d3</citedby><cites>FETCH-LOGICAL-c4071-c99f6fba276960e4715cca79a6ecbb1b2b369cb70c3e76beaa3ec57000062a6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550040511$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550040511$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8942177$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6512164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Descotes, Jacques</creatorcontrib><creatorcontrib>Evreux, Jean Claude</creatorcontrib><creatorcontrib>Laschi-Locquerie, Alda</creatorcontrib><creatorcontrib>Tachon, Pierre</creatorcontrib><title>Comparative effects of various lead salts on delayed hypersensitivity in mice</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell‐mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbonates - toxicity</subject><subject>cell-mediated immunity</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Female</subject><subject>Hypersensitivity, Delayed</subject><subject>Immunity, Cellular - drug effects</subject><subject>immunotoxicity</subject><subject>Lead - toxicity</subject><subject>lead salts</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nitrates - toxicity</subject><subject>Organometallic Compounds</subject><subject>Toxicology</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EglK4ckPygWuK7SQ2PqKK8lALEpSHuFgbZyMMaRvZaSH_nqBURZw4rbQz3-5oCDnibMAZE6fvUA9EmjKWsJTzLdLjTOuICxlvkx4TkkVJrF72yH4I74y1mjjbJbsy5YLLpEcmw8WsAg-1WyHFokBbB7oo6Aq8WywDLRFyGqD82c5pjiU0mNO3pkIfcB5cy7m6oW5OZ87iAdkpoAx4uJ598ji6mA6vovHd5fXwfBzZhCkeWa0LWWQglNSSYaJ4ai0oDRJtlvFMZLHUNlPMxqhkhgAx2lS18ZkUIPO4TwbdXesXIXgsTOXdDHxjODM_tZi2FvNbSwscd0C1zGaYb-zrHlr9ZK1DsFAWHubWhY3tTCeCK9XadGf7dCU2_zw1N-fTPxGijnWhxq8NC_7DSBWr1DzfXprXydPz_dXowaTxN2ARi6U</recordid><startdate>198410</startdate><enddate>198410</enddate><creator>Descotes, Jacques</creator><creator>Evreux, Jean Claude</creator><creator>Laschi-Locquerie, Alda</creator><creator>Tachon, Pierre</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198410</creationdate><title>Comparative effects of various lead salts on delayed hypersensitivity in mice</title><author>Descotes, Jacques ; Evreux, Jean Claude ; Laschi-Locquerie, Alda ; Tachon, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4071-c99f6fba276960e4715cca79a6ecbb1b2b369cb70c3e76beaa3ec57000062a6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbonates - toxicity</topic><topic>cell-mediated immunity</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Female</topic><topic>Hypersensitivity, Delayed</topic><topic>Immunity, Cellular - drug effects</topic><topic>immunotoxicity</topic><topic>Lead - toxicity</topic><topic>lead salts</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nitrates - toxicity</topic><topic>Organometallic Compounds</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Descotes, Jacques</creatorcontrib><creatorcontrib>Evreux, Jean Claude</creatorcontrib><creatorcontrib>Laschi-Locquerie, Alda</creatorcontrib><creatorcontrib>Tachon, Pierre</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Descotes, Jacques</au><au>Evreux, Jean Claude</au><au>Laschi-Locquerie, Alda</au><au>Tachon, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effects of various lead salts on delayed hypersensitivity in mice</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1984-10</date><risdate>1984</risdate><volume>4</volume><issue>5</issue><spage>265</spage><epage>266</epage><pages>265-266</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell‐mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>6512164</pmid><doi>10.1002/jat.2550040511</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of applied toxicology, 1984-10, Vol.4 (5), p.265-266 |
| issn | 0260-437X 1099-1263 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Carbonates - toxicity cell-mediated immunity Chemical and industrial products toxicology. Toxic occupational diseases Female Hypersensitivity, Delayed Immunity, Cellular - drug effects immunotoxicity Lead - toxicity lead salts Male Medical sciences Metals and various inorganic compounds Mice Mice, Inbred BALB C Nitrates - toxicity Organometallic Compounds Toxicology |
| title | Comparative effects of various lead salts on delayed hypersensitivity in mice |
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