Comparative effects of various lead salts on delayed hypersensitivity in mice

Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead ca...

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Veröffentlicht in:	Journal of applied toxicology 1984-10, Vol.4 (5), p.265-266
Hauptverfasser:	Descotes, Jacques, Evreux, Jean Claude, Laschi-Locquerie, Alda, Tachon, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbonates - toxicity cell-mediated immunity Chemical and industrial products toxicology. Toxic occupational diseases Female Hypersensitivity, Delayed Immunity, Cellular - drug effects immunotoxicity Lead - toxicity lead salts Male Medical sciences Metals and various inorganic compounds Mice Mice, Inbred BALB C Nitrates - toxicity Organometallic Compounds Toxicology
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Beschreibung
Zusammenfassung:	Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell‐mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.
ISSN:	0260-437X 1099-1263
DOI:	10.1002/jat.2550040511