The role of dynamic interplay exists between sympathetic and parasympathetic nerve in gastric tumorigenesis (2/2024)

The illustration demonstrates the dynamic process of nerve remodeling during gastric precancerous progression. The density of parasympathetic nerve and Schwann cell exhibited a gradual increase, whereas the sympathetic nerve showed a reduced trend across the spectrum of precancerous lesions. There is a dynamic relationship between sympathetic and parasympathetic nerves resulting from crosstalk among inflammation, immune regulation, and neural regulation during gastric tumorigenesis. This specific pattern of nerve distribution is validated by gene‐level nerve‐related signatures. Several key nerve‐regulating genes and pathways, such as MAPK/ERK, PI3K/AKT/mTOR signaling are also identified. These findings highlight the importance of comprehending the interaction between nerves and tumor cells, offering potential avenues for future clinical translation targeting the nervous system and disrupting nerves‐cancer crosstalk.