Deoxyfluorination of (Hetero)aryl Aldehydes Using Tetramethylammonium Fluoride and Perfluorobutanesulfonyl Fluoride or Trifluoromethanesulfonic Anhydride

Deoxyfluorination of (Hetero)aryl Aldehydes Using Tetramethylammonium Fluoride and Perfluorobutanesulfonyl Fluoride or Trifluoromethanesulfonic Anhydride

This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.

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Bibliographische Detailangaben
Veröffentlicht in:Israel journal of chemistry 2020-03, Vol.60 (3-4), p.398-401
Hauptverfasser: Ferguson, Devin M., Melvin, Patrick R., Sanford, Melanie S.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Anhydrides
Aromatic compounds
Chemistry
Chemistry, Multidisciplinary
deoxyfluorination
difluoromethylation
Fluorides
fluorination
fluoroalkylation
Physical Sciences
Science & Technology
tetramethylammonium fluoride
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Beschreibung
Zusammenfassung:This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.201900066