Transformation of mouse cells after infection with ultraviolet irradiation‐inactivated herpes simplex virus type 2
A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation‐inactivated herpes simplex virus type 2 (HSV‐2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6‐week‐old syngeneic BALB/c mice at an inoculu...
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| Veröffentlicht in: | International journal of cancer 1975-10, Vol.16 (4), p.526-538 |
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| container_title | International journal of cancer |
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| creator | Boyd, Ann Lewis Orme, Thomas W. |
| description | A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation‐inactivated herpes simplex virus type 2 (HSV‐2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6‐week‐old syngeneic BALB/c mice at an inoculum of 1 × 106. Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV‐2 were found in the sera of tumor‐bearing animals by neutralization and IF techniques. Neither HSV‐2 infectious virus nor viral antigens could be detected by the transfer of transformed‐cell DNA into permissive cells. |
| doi_str_mv | 10.1002/ijc.2910160403 |
| format | Article |
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The transformed cells produced tumors with a 100% incidence within 8 weeks in 6‐week‐old syngeneic BALB/c mice at an inoculum of 1 × 106. Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV‐2 were found in the sera of tumor‐bearing animals by neutralization and IF techniques. Neither HSV‐2 infectious virus nor viral antigens could be detected by the transfer of transformed‐cell DNA into permissive cells.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.2910160403</identifier><identifier>PMID: 170223</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Antibodies, Viral ; Antibody Specificity ; Antigens, Viral ; Cell Line ; Cell Transformation, Neoplastic ; DNA, Neoplasm - isolation & purification ; DNA, Viral - isolation & purification ; In Vitro Techniques ; Mice ; Mice, Inbred BALB C ; Neoplasm Transplantation ; Neoplasms, Experimental - immunology ; Neutralization Tests ; Radiation Effects ; Simplexvirus - immunology ; Simplexvirus - radiation effects ; Transplantation, Isogeneic ; Ultraviolet Rays</subject><ispartof>International journal of cancer, 1975-10, Vol.16 (4), p.526-538</ispartof><rights>Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3393-6ae9807af1405c8527e42527fe13a0225b0385b35f230a4fa44e62b3744422043</citedby><cites>FETCH-LOGICAL-c3393-6ae9807af1405c8527e42527fe13a0225b0385b35f230a4fa44e62b3744422043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.2910160403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.2910160403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/170223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyd, Ann Lewis</creatorcontrib><creatorcontrib>Orme, Thomas W.</creatorcontrib><title>Transformation of mouse cells after infection with ultraviolet irradiation‐inactivated herpes simplex virus type 2</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation‐inactivated herpes simplex virus type 2 (HSV‐2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6‐week‐old syngeneic BALB/c mice at an inoculum of 1 × 106. Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV‐2 were found in the sera of tumor‐bearing animals by neutralization and IF techniques. Neither HSV‐2 infectious virus nor viral antigens could be detected by the transfer of transformed‐cell DNA into permissive cells.</description><subject>Animals</subject><subject>Antibodies, Viral</subject><subject>Antibody Specificity</subject><subject>Antigens, Viral</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>DNA, Viral - isolation & purification</subject><subject>In Vitro Techniques</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Neutralization Tests</subject><subject>Radiation Effects</subject><subject>Simplexvirus - immunology</subject><subject>Simplexvirus - radiation effects</subject><subject>Transplantation, Isogeneic</subject><subject>Ultraviolet Rays</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi3ErRRWJga_QMrxJUkzoopCUSWWMkdOeqy6ci6ynZZuPALPyJMQWqSysZx_-C86-gi5ZTBiAPzerMsRzxiwBCSIEzJgkKURcBafkkEfgChlIrkkV96vARiLQV6Qc5YC52JAwsKp2uvGVSqYpqaNplXTeaQlWuup0gEdNbXGcm9vTVjRzganNqaxGKhxTi3Nvvv18Wlq1ec2KuCSrtC16Kk3VWvxnW6M6zwNuxYpvyZnWlmPN786JG_Tx8XkOZq_Ps0mD_OoFCITUaIwG0OqNJMQl-OYpyh5fzUyofr34wLEOC5ErLkAJbWSEhNeiFRKyTlIMSSjw27pGu8d6rx1plJulzPIf-DlPbz8CK8v3B0KbVdUuDzG97R6OzvYW2Nx989YPnuZ_Jn-BlJufT8</recordid><startdate>19751015</startdate><enddate>19751015</enddate><creator>Boyd, Ann Lewis</creator><creator>Orme, Thomas W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19751015</creationdate><title>Transformation of mouse cells after infection with ultraviolet irradiation‐inactivated herpes simplex virus type 2</title><author>Boyd, Ann Lewis ; Orme, Thomas W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3393-6ae9807af1405c8527e42527fe13a0225b0385b35f230a4fa44e62b3744422043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Antibodies, Viral</topic><topic>Antibody Specificity</topic><topic>Antigens, Viral</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>DNA, Viral - isolation & purification</topic><topic>In Vitro Techniques</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Neutralization Tests</topic><topic>Radiation Effects</topic><topic>Simplexvirus - immunology</topic><topic>Simplexvirus - radiation effects</topic><topic>Transplantation, Isogeneic</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyd, Ann Lewis</creatorcontrib><creatorcontrib>Orme, Thomas W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyd, Ann Lewis</au><au>Orme, Thomas W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transformation of mouse cells after infection with ultraviolet irradiation‐inactivated herpes simplex virus type 2</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1975-10-15</date><risdate>1975</risdate><volume>16</volume><issue>4</issue><spage>526</spage><epage>538</epage><pages>526-538</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation‐inactivated herpes simplex virus type 2 (HSV‐2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6‐week‐old syngeneic BALB/c mice at an inoculum of 1 × 106. Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV‐2 were found in the sera of tumor‐bearing animals by neutralization and IF techniques. Neither HSV‐2 infectious virus nor viral antigens could be detected by the transfer of transformed‐cell DNA into permissive cells.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>170223</pmid><doi>10.1002/ijc.2910160403</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 1975-10, Vol.16 (4), p.526-538 |
| issn | 0020-7136 1097-0215 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antibodies, Viral Antibody Specificity Antigens, Viral Cell Line Cell Transformation, Neoplastic DNA, Neoplasm - isolation & purification DNA, Viral - isolation & purification In Vitro Techniques Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms, Experimental - immunology Neutralization Tests Radiation Effects Simplexvirus - immunology Simplexvirus - radiation effects Transplantation, Isogeneic Ultraviolet Rays |
| title | Transformation of mouse cells after infection with ultraviolet irradiation‐inactivated herpes simplex virus type 2 |
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