Asymmetric Total Synthesis of Stagonolide G

Asymmetric Total Synthesis of Stagonolide G

A simple asymmetric total synthesis of stagonolide G (1) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐catalyzed ring‐closing metathesis (RCM).

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Helvetica chimica acta 2011-07, Vol.94 (7), p.1226-1233
Hauptverfasser: Ramesh, Dasari, Rajaram, Singanaboina, Prabhakar, Peddikotla, Ramulu, Udugu, Kumar Reddy, Dorigondla, Venkateswarlu, Yenamandra
Format: Artikel
Sprache:eng
Schlagworte:
Dihydroxylation
Epoxide opening
Grignard reaction
Ring-closing methathesis
Stagonolide G
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A simple asymmetric total synthesis of stagonolide G (1) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐catalyzed ring‐closing metathesis (RCM).
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201000416