New Acyclic 12-Hydroxygeranylgeraniol-Derived Diterpenoids from the Seeds of Carpesium triste

New Acyclic 12-Hydroxygeranylgeraniol-Derived Diterpenoids from the Seeds of Carpesium triste

Five new acyclic 12‐hydroxygeranylgeraniol‐derived diterpenoids, i.e., 1–5, were isolated from the seeds of Carpesium triste. The structures including the absolute configurations of the new compounds were elucidated by spectroscopic methods. All the compounds, except for 2, were evaluated for their...

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Veröffentlicht in:Helvetica chimica acta 2008-10, Vol.91 (10), p.1934-1939
Hauptverfasser: Gao, Xue, Zhang, Zhan-Xin, Jia, Zhong-Jian
Format: Artikel
Sprache:eng
Schlagworte:
Carpesium triste
Cytotoxic activity
Diterpenoids
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Zusammenfassung:Five new acyclic 12‐hydroxygeranylgeraniol‐derived diterpenoids, i.e., 1–5, were isolated from the seeds of Carpesium triste. The structures including the absolute configurations of the new compounds were elucidated by spectroscopic methods. All the compounds, except for 2, were evaluated for their in vitro cytotoxic activity against cultured SMMC‐7721 (human hepatoma), HL‐60 (human promyelocytic leukemia), and L02 (human hepatocyte) cells.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200890206