Modified Cyclodextrins as Enantioselective Hosts for Amino Acids

Modified Cyclodextrins as Enantioselective Hosts for Amino Acids

Two modified β‐cyclodextrins, H‐2 and H‐3, having a flexible appended moiety were studied for the chiral discrimination of the enantiomers of various amino acids by means of fluorescence as signaling option. These hosts quenched the fluorescence intensities of amino acids upon binding. The d‐enantio...

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Veröffentlicht in:Helvetica chimica acta 2008-04, Vol.91 (4), p.753-758
Hauptverfasser: Kumar, Vydyula Pavan, Suryanarayana, Iragavarapu, Nageswar, Yadavalli Venkata Durga, Rao, Kakulapati Rama
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Cyclodextrin
Enantiomer discrimination
Enantioselectivity factor
Stability constants
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Zusammenfassung:Two modified β‐cyclodextrins, H‐2 and H‐3, having a flexible appended moiety were studied for the chiral discrimination of the enantiomers of various amino acids by means of fluorescence as signaling option. These hosts quenched the fluorescence intensities of amino acids upon binding. The d‐enantiomers were better recognized by these hosts. The association constants (Ks) and enantioselectivity factors (α) of the host⋅guest complexes were calculated.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200890077