One-Pot Three-Component Synthesis of α-Amino Nitriles Catalyzed by 2,4,6-Trichloro-1,3,5-triazine (Cyanuric Acid)

A simple and efficient method has been developed for the synthesis of α‐amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.

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Bibliographische Detailangaben
Veröffentlicht in:	Helvetica chimica acta 2007-06, Vol.90 (6), p.1206-1210
Hauptverfasser:	Das, Biswanath, Kumar, Rathod Aravind, Thirupathi, Ponnaboina
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,5‐Triazine, 2,4,6‐trichloro 5-Triazine 6-trichloro Cyanuric acid Nitriles Nitriles, α‐amino One-pot three-component synthesis Strecker-type reaction Trimethylsilyl cyanide α-amino
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Beschreibung
Zusammenfassung:	A simple and efficient method has been developed for the synthesis of α‐amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.
ISSN:	0018-019X 1522-2675
DOI:	10.1002/hlca.200790119