Rubescensins S and T: Seco-ent-Kaurane Diterpenoids from Isodon rubescens var. taihangensis

Rubescensins S and T: Seco-ent-Kaurane Diterpenoids from Isodon rubescens var. taihangensis

Two new diterpenoids, rubescensin S (=(1α,6β,14β)‐7α,20‐epoxy‐1,7,14‐trihydroxy‐16‐oxo‐15,16‐seco‐ent‐kauran‐6,15‐olide; 1) and rubescensin T (=(1α,6β,11β,20S)‐7α,20‐epoxy‐1,6,7‐trihydroxy‐20‐methoxy‐8,15‐seco‐ent‐kaur‐16‐en‐11,15‐olide; 2) were isolated from the Chinese medicinal herb Isodon rubesc...

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Veröffentlicht in:Helvetica chimica acta 2004-05, Vol.87 (5), p.1119-1124
Hauptverfasser: Han, Quan-Bin, Li, Rong-Tao, Zhang, Ji-Xia, Sun, Han-Dong
Format: Artikel
Sprache:eng
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Zusammenfassung:Two new diterpenoids, rubescensin S (=(1α,6β,14β)‐7α,20‐epoxy‐1,7,14‐trihydroxy‐16‐oxo‐15,16‐seco‐ent‐kauran‐6,15‐olide; 1) and rubescensin T (=(1α,6β,11β,20S)‐7α,20‐epoxy‐1,6,7‐trihydroxy‐20‐methoxy‐8,15‐seco‐ent‐kaur‐16‐en‐11,15‐olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16‐seco‐ent‐kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200490102