Template-Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn-Inducing Mimics

Template-Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn-Inducing Mimics

The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (1), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (2), and 8‐(aminomethyl)naphth‐2‐oic acid (3) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them (2 and 3) were incorporated into a novel type of cyclic, pep...

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Veröffentlicht in:Helvetica chimica acta 1993-06, Vol.76 (4), p.1539-1563
Hauptverfasser: Earnest, Ivan, Kalvoda, Jaroslav, Francotte, Eric, Rihs, Grety, Fritz, Hans, Blommers, Marcel J. J., Raschdorf, Fritz, Sigel, Christoph, Mutter, Manfred
Format: Artikel
Sprache:eng
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Zusammenfassung:The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (1), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid (2), and 8‐(aminomethyl)naphth‐2‐oic acid (3) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them (2 and 3) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34–36) designed as templates for the synthesis of TASP molecules.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.19930760414