A Synthesis of 1 D ‐ and 1 L ‐ myo ‐Inositol 1,3,4,5,‐Tetraphosphate

A synthesis of 1 D ‐ and 1 L ‐ myo ‐inositol 1,3,4,5,‐tetraphosphate ( 1a and 1b resp.) is described. The dibenzylated myo ‐inositola 9a and 9b , which, by phosphorylation, gave 1a and 1b , respectively, were prepared via two routes. On the one hand, the racemate 3a/3b , obtained from myo ‐inositol, was resolved by its transformation into the diastereoisomeric carbamates 5a and 5b . Benzylation and deprotecton of 5a and 5b gave the enantiomers 9a and 9b , respectively. On the other hand, treatment of the diester 18 with pig liver esterase gave the ester 21a with high enantiomeric excess. Benzylation and deprotection of 21a yielded 9b . The dibenzyl derivative 9a was obtained using the same enzymatic hydrolysis followed by a protection‐deprotection sequence.