Stoffwechselprodukte von Mikroorganismen. 219. Mitteilung. Versuche zur Strukturaufklärung von Niphimycin, 2. Teil. Die Konstitution von Desmalonyl‐niphimycin I
On the Structural Elucidation of Niphimycin, Part II. The Constitution of Demalonylniphimycin I A stepwise degradation of copiamycin and niphimycin I with ozone and sodium periodate, partly combined with D‐labelling, and intense spectroscopic investigations of the degradation products led to the str...
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Veröffentlicht in: | Helvetica chimica acta 1983-02, Vol.66 (1), p.226-258 |
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description | On the Structural Elucidation of Niphimycin, Part II. The Constitution of Demalonylniphimycin I
A stepwise degradation of copiamycin and niphimycin I with ozone and sodium periodate, partly combined with D‐labelling, and intense spectroscopic investigations of the degradation products led to the structural formulae 34 for demalonylcopiamycin (in agreement with the structure proposed by Iwasaki et al. for the same antibiotic) and 38 for demalonylniphimycin. The antibiotics copiamycin and niphimycin are half esters of malonic acid and the macrolide polyols 34 and 38, resp., with uncertain positions of the malonyl residues. |
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A stepwise degradation of copiamycin and niphimycin I with ozone and sodium periodate, partly combined with D‐labelling, and intense spectroscopic investigations of the degradation products led to the structural formulae 34 for demalonylcopiamycin (in agreement with the structure proposed by Iwasaki et al. for the same antibiotic) and 38 for demalonylniphimycin. The antibiotics copiamycin and niphimycin are half esters of malonic acid and the macrolide polyols 34 and 38, resp., with uncertain positions of the malonyl residues.</description><identifier>ISSN: 0018-019X</identifier><identifier>EISSN: 1522-2675</identifier><identifier>DOI: 10.1002/hlca.19830660124</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><ispartof>Helvetica chimica acta, 1983-02, Vol.66 (1), p.226-258</ispartof><rights>Copyright © 1983 Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2084-95fd816436550fddfc80df5bf28160f8290777b911802824f672a8550389cef3</citedby><cites>FETCH-LOGICAL-c2084-95fd816436550fddfc80df5bf28160f8290777b911802824f672a8550389cef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhlca.19830660124$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhlca.19830660124$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Keller‐Schierlein, Walter</creatorcontrib><creatorcontrib>Joos, Beda</creatorcontrib><creatorcontrib>Kaiser, Hans‐Peter</creatorcontrib><creatorcontrib>Gassmann, Peter</creatorcontrib><title>Stoffwechselprodukte von Mikroorganismen. 219. Mitteilung. Versuche zur Strukturaufklärung von Niphimycin, 2. Teil. Die Konstitution von Desmalonyl‐niphimycin I</title><title>Helvetica chimica acta</title><description>On the Structural Elucidation of Niphimycin, Part II. The Constitution of Demalonylniphimycin I
A stepwise degradation of copiamycin and niphimycin I with ozone and sodium periodate, partly combined with D‐labelling, and intense spectroscopic investigations of the degradation products led to the structural formulae 34 for demalonylcopiamycin (in agreement with the structure proposed by Iwasaki et al. for the same antibiotic) and 38 for demalonylniphimycin. The antibiotics copiamycin and niphimycin are half esters of malonic acid and the macrolide polyols 34 and 38, resp., with uncertain positions of the malonyl residues.</description><issn>0018-019X</issn><issn>1522-2675</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNqFkEtOwzAURS0EEqUwZ-gFkPDs_JwBg6oFWlFg0Aoxi9LEbkzTpLIdqjBiCewBdsJOWAkuRagzRk-6OudK7yJ0SsAlAPS8KLPUJTHzIAyBUH8PdUhAqUPDKNhHHQDCHCDx4yE60voJAOIYog56n5haiDXPCs3LlarzZmE4fq4rfCsXqq7VPK2kXvLKxZTErk2N4bJsqrmLH7jSTVZw_NIoPDHKqo1KG7EoPz-UJX5q7uSqkMs2k9UZpi6eWtnFA8nxTV1pI01jpKU25IDrZVrWVVt-vb5VfxoeHaMDkZaan_zeLppeXU77Q2d8fz3q98ZORoH5ThyInJHQ98IgAJHnImOQi2AmqE1BMGofjqJZTAgDyqgvwoimzLIeizMuvC6CbW2maq0VF8lKyWWq2oRAstk42Wyc7GxslYutspYlb__lk-G439v1vwGLX4ZK</recordid><startdate>19830202</startdate><enddate>19830202</enddate><creator>Keller‐Schierlein, Walter</creator><creator>Joos, Beda</creator><creator>Kaiser, Hans‐Peter</creator><creator>Gassmann, Peter</creator><general>WILEY‐VCH Verlag GmbH</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19830202</creationdate><title>Stoffwechselprodukte von Mikroorganismen. 219. Mitteilung. Versuche zur Strukturaufklärung von Niphimycin, 2. Teil. Die Konstitution von Desmalonyl‐niphimycin I</title><author>Keller‐Schierlein, Walter ; Joos, Beda ; Kaiser, Hans‐Peter ; Gassmann, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2084-95fd816436550fddfc80df5bf28160f8290777b911802824f672a8550389cef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller‐Schierlein, Walter</creatorcontrib><creatorcontrib>Joos, Beda</creatorcontrib><creatorcontrib>Kaiser, Hans‐Peter</creatorcontrib><creatorcontrib>Gassmann, Peter</creatorcontrib><collection>CrossRef</collection><jtitle>Helvetica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller‐Schierlein, Walter</au><au>Joos, Beda</au><au>Kaiser, Hans‐Peter</au><au>Gassmann, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stoffwechselprodukte von Mikroorganismen. 219. Mitteilung. Versuche zur Strukturaufklärung von Niphimycin, 2. Teil. Die Konstitution von Desmalonyl‐niphimycin I</atitle><jtitle>Helvetica chimica acta</jtitle><date>1983-02-02</date><risdate>1983</risdate><volume>66</volume><issue>1</issue><spage>226</spage><epage>258</epage><pages>226-258</pages><issn>0018-019X</issn><eissn>1522-2675</eissn><abstract>On the Structural Elucidation of Niphimycin, Part II. The Constitution of Demalonylniphimycin I
A stepwise degradation of copiamycin and niphimycin I with ozone and sodium periodate, partly combined with D‐labelling, and intense spectroscopic investigations of the degradation products led to the structural formulae 34 for demalonylcopiamycin (in agreement with the structure proposed by Iwasaki et al. for the same antibiotic) and 38 for demalonylniphimycin. The antibiotics copiamycin and niphimycin are half esters of malonic acid and the macrolide polyols 34 and 38, resp., with uncertain positions of the malonyl residues.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><doi>10.1002/hlca.19830660124</doi><tpages>33</tpages></addata></record> |
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title | Stoffwechselprodukte von Mikroorganismen. 219. Mitteilung. Versuche zur Strukturaufklärung von Niphimycin, 2. Teil. Die Konstitution von Desmalonyl‐niphimycin I |
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