Nucleosides and Nucleotides. Part 13. Synthesis and spectral properties of 1- (3′-O-Phosphoryl-2′-deoxy-β -D-ribofuranosyl)-2(1H)-pyridone-(3′-5′)-1-(2′-deoxy-β-D-ribofuranosyl)-2 (1H)-pyridone

The dinucleoside phosphate ΠdpΠd (4) was synthesized from the monomers 1‐(5′‐O‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 H) ‐ pyridone ((MeOTr) Πd, 2) and 1‐(5′‐O‐phosphoryl‐3′‐O‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1H)‐pyridone (pΠd(Ac), 3). Its 6.4% hyperchromicity and an analysis of the 1H‐NMR. spectra indicate that the conformation and the base‐base interactions in 4 are similar to those in natural pyrimidine dinucleoside phosphates.