Ammonolysis of Nitroarginine and Nitroarginine-Containing Peptides; Some Side Reactions

Ammonolysis of Nitroarginine and Nitroarginine-Containing Peptides; Some Side Reactions

Ammonolysis of nitroarginine‐containing peptides leads to the formation of ornithine‐containing side products. The structure of these side products has been deduced from model experiments. This side reaction can be avoided by using the NG‐tosyl or the NG‐dicarbobenzoxy protecting groups.

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Veröffentlicht in:Helvetica chimica acta 1974-04, Vol.57 (3), p.566-572
Hauptverfasser: Künzi, Hans, Manneberg, Michael, Studer, Rolf O.
Format: Artikel
Sprache:eng
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Zusammenfassung:Ammonolysis of nitroarginine‐containing peptides leads to the formation of ornithine‐containing side products. The structure of these side products has been deduced from model experiments. This side reaction can be avoided by using the NG‐tosyl or the NG‐dicarbobenzoxy protecting groups.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.19740570310