Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals

Results from the testing of 108 coded chemicals in Chinese hamster ovary (CHO) cells for the induction of chromosome aberrations and sister chromatid exchanges (SCEs) are presented. All chemicals were tested with and without exogenous metabolic activation, using protocols designed to allow testing u...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1987, Vol.10 (S10), p.1-35
Hauptverfasser:	Galloway, S. M., Armstrong, M. J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A. D., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B. H., Resnick, M. A., Anderson, B., Zeiger, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Cell Cycle - drug effects Cell Line Chemical mutagenesis Chromosome Aberrations Cricetinae Cricetulus data analysis Female Fibroblasts - drug effects In vitro chemical testing Male mammalian cells Medical sciences metabolic activation Microsomes, Liver - metabolism Mutagenicity Tests Ovary Rats Rats, Inbred Strains Sister Chromatid Exchange - drug effects Toxicology
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Zusammenfassung:	Results from the testing of 108 coded chemicals in Chinese hamster ovary (CHO) cells for the induction of chromosome aberrations and sister chromatid exchanges (SCEs) are presented. All chemicals were tested with and without exogenous metabolic activation, using protocols designed to allow testing up to toxic doses. Cell harvest times could also be extended if chemical‐induced cell cycle delay was seen. Chromosome aberrations were induced by 43 of the chemicals, and 66 induced SCEs; 37 of the chemicals were positive for both endpoints.
ISSN:	0893-6692 1098-2280
DOI:	10.1002/em.2850100502