Inside Front cover: Minimization of artifact protein aggregation using tetradecyl sulfate and hexadecyl sulfate in capillary gel electrophoresis under reducing conditions

DOI: 10.1002/elps.201900435 The inside cover picture shows the use of novel “CE‐SCXS” methods that utilize alternative detergents to SDS, such as sodium tetradecyl sulfate (STS) or sodium hexadecyl sulfate (SHS), for capillary gel electrophoresis (CGE) analysis of therapeutic mAbs. These detergents...

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Veröffentlicht in:Electrophoresis 2020-07, Vol.41 (13-14), p.NA
Hauptverfasser: Guan, Qian, Atsma, Jennifer, Tulsan, Rekha, Voronov, Sergey, Ding, Julia, Beckman, Jeff, Li, Zheng Jian
Format: Artikel
Sprache:eng
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Zusammenfassung:DOI: 10.1002/elps.201900435 The inside cover picture shows the use of novel “CE‐SCXS” methods that utilize alternative detergents to SDS, such as sodium tetradecyl sulfate (STS) or sodium hexadecyl sulfate (SHS), for capillary gel electrophoresis (CGE) analysis of therapeutic mAbs. These detergents ensure maintenance of a denatured detergent:protein complex prior to and during capillary separation, as shown by the minimization of method‐induced artifacts under reducing conditions compared to the use of SDS alone. Inside cover design is by Qian Guan.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.202070072