In Vivo Detection of Hydrogen Sulfide in Brain and Cell

Hydrogen sulfide (H2S), is proposed as a cytoprotectant and gasotransmitter, involving in many physiological processes and regulating of some diseases. In addition, H2S is a small molecular with a minimum of steric hindrance compared with other reactive sulfur species. In physiological atmosphere, H2S is mainly existent in HS−, which has a strong nucleophilicity and reducing potency. It also can precipitate with some metal ions forming metallic sulfides with high precipitation coefficient. In recent years, the researchers have a desire to develop methods to achieve real‐time detection of H2S in vivo, further understanding the physiology and pathology of H2S. In this minireview, we summarize recent progress for detecting of H2S in brain or cell and briefly expound the principle of methods with the comparison of the different methods between performance and temporal resolution.