Voltammetry and EQCM Investigation of Glutathione Monolayer and Its Complexation with Cu 2

The glutathione (GSH) self‐assembled monolayer and its compexlation with Cu 2+ were studied by using voltammetry and EQCM. It was found that the monolayer could rearrange during the redox process of Cu 2+ /Cu + . The protonating, or not, of the carboxyl terminates of the adsorpted GSH molecules influence the compexlation interaction significantly for they are the key binding sites. The GSH monolayer had the capacity to accumulate Cu 2+ and the monolayer modified gold electrode was employed to detect the low levels of Cu 2+ with a limit of 1.0×10 −10 mol L −1 .