Acid‐Controlled Regional Diverse Synthesis of CF 3 ‐Containing Ketoimines and Application in the Construction of Bispiro[oxindole‐pyrrolidine‐benzothiophenone]s

Here described an acid‐controlled regional diverse synthesized process of CF 3 ‐containing ketoimines by the condensation of benzo[ b ]thiophene‐2,3‐dione and 2,2,2‐trifluoroethlamine. The imines obtained at either the 2‐position or 3‐position can be further used as substrates in asymmetric organocatalyzed [3+2]‐cycloaddition reactions, leading to a library of regiodiverse bispiro‐compounds with 85–96 % yield and 65–99 % ee .