Saturated Bicyclic Sultams

Saturated bicyclic sultams represent a promising class of sp3‐rich three‐dimensional scaffolds of outmost importance to organic and medicinal chemistry. In this review with 99 references, synthesis, properties, and applications of these compounds are surveyed. The literature data are categorized according to the structural types (i.e. fused, bridged, and spirocyclic compounds), as well as homologous series (from β‐ to ε‐sultams). It is shown that most of the approaches are based on the construction of the sultam ring; these methods include intramolecular N‐sulfonylations, sulfonamide N‐alkylations, carbanion‐mediated sulfonamide intramolecular cyclizations (CSIC), ring‐closing metathesis, Michael additions, aza‐Prins reaction, as well as both intra‐ and intermolecular [2+2] and [3+2] cycloadditions and other transformations. A review with 99 references discussing synthesis, chemical, and conformational properties, and medicinal chemistry applications of saturated bicyclic sultams. The literature data are categorized according to the structural type of the title compounds (i.e. fused, bridged, or spirocyclic), as well as to the sultam ring size (β‐ to ε‐sultams).