Synthesis of Thiazolidine‐2‐thiones through a One‐Pot A 3 ‐Coupling–Carbon Disulfide Incorporation Process

Synthesis of Thiazolidine‐2‐thiones through a One‐Pot A 3 ‐Coupling–Carbon Disulfide Incorporation Process

A copper‐catalyzed two‐step one‐pot procedure for the synthesis of thiazolidine‐2‐thiones has been developed. The process involves a three‐component coupling of an alkyne, an aldehyde, and an amine (A 3 ‐coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent...

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Veröffentlicht in:European journal of organic chemistry 2017-02, Vol.2017 (6), p.1063-1069
Hauptverfasser: Nechaev, Anton A., Peshkov, Anatoly A., Van Hecke, Kristof, Peshkov, Vsevolod A., Van der Eycken, Erik V.
Format: Artikel
Sprache:eng
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Zusammenfassung:A copper‐catalyzed two‐step one‐pot procedure for the synthesis of thiazolidine‐2‐thiones has been developed. The process involves a three‐component coupling of an alkyne, an aldehyde, and an amine (A 3 ‐coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent cyclization.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201601103