Asymmetric Aldol Reaction of α,α-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers

The asymmetric cross‐aldol reaction of α,α‐disubstituted acetaldehydes with commercial ethyl glyoxylate polymer was successfully catalyzed by diphenylprolinol silyl ether 3 to generate all‐carbon quaternary stereogenic centers with good enantioselectivity. Diphenylprolinol silyl ether is an effective organocatalyst in the asymmetric cross‐aldol reaction of α,α‐disubstituted acetaldehydes with commercial ethyl glyoxylate polymer to generate all‐carbon quaternary stereogenic centers with good enantioselectivity.