Versatile Synthesis of 1‐ O ‐(ω‐Aminolauryl)‐I(4,5)P 2

The synthesis of a model 1‐ O ‐(ω‐aminoacyl)‐IP 2 derivative, lauryl 4,5‐bisphosphate 31 , was realized following a versatile and high‐yielding scheme. The flexible synthetic strategy used for this purpose allows the preparation of a range of other useful IP, IP 2 and IP 3 derivatives. In view of th...

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Veröffentlicht in:European journal of organic chemistry 2012-10, Vol.2012 (29), p.5855-5862
Hauptverfasser: Varvogli, Anastasia‐Aikaterini C., Fylaktakidou, Konstantina C., Farmaki, Theodora, Stefanakis, John G., Koumbis, Alexandros E.
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis of a model 1‐ O ‐(ω‐aminoacyl)‐IP 2 derivative, lauryl 4,5‐bisphosphate 31 , was realized following a versatile and high‐yielding scheme. The flexible synthetic strategy used for this purpose allows the preparation of a range of other useful IP, IP 2 and IP 3 derivatives. In view of the central role played by IPs and PIPs in cellular life, the preparation of functionalized myo ‐inositol derivatives of this type may facilitate the isolation and fluorescent localization of related proteins.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201200726