Solvent-Free Tandem Synthesis of 2-Thiazolines and 2-Oxazolines Catalyzed by a Copper Catalyst

Tandem reactions of nitriles with 2‐aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (CuII2L4, L = methacrylate) were employed to prepare 2‐thiazolines and 2‐oxazolines under mild reaction conditions. The synthetic procedure showed high selectivity for the synthesis of mono‐ and bis‐thiazolines and oxazolines, and a variety of 2‐thiazolines and 2‐oxazolines was obtained in good to excellent yields. Tandem reactions of nitriles with 2‐aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate were employed to prepare 2‐thiazolines and 2‐oxazolines under solvent‐free conditions.