A Carbohydrate-Based Synthesis of the C13-C22 Fragment of Amphidinolide X

A facile carbohydrate‐based route was developed for the synthesis of the tetrahydrofuran (C13–C22) fragment of amphidinolide X. Starting from L‐sorbose, the key reactions followed include the stereoselective synthesis of a quaternary center at C1, Barton–McCombie deoxygenation at C2, Mitsunobu inversion at C3, and chain elongation by a Wittig reaction at C5. Synthesis of the C13–C22 fragment of amphidinolide X was achieved followingstereoselective installation of a quaternary center at C1, Barton–McCombie deoxygenation at C2, Mitsunobu inversion at C3, and chain elongation by a Wittig reaction at C5 as key reactions starting from L‐sorbose.