Synthesis of Biaryls through a One-Pot Tandem Borylation/Suzuki-Miyaura Cross-Coupling Reaction Catalyzed by a Palladacycle
The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one‐pot borylation/Suzuki–Miyaura coupling (BSC) reaction with low catalyst loading (2 mol‐%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was a...
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Veröffentlicht in: | European Journal of Organic Chemistry 2012-01, Vol.2012 (3), p.595-603 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one‐pot borylation/Suzuki–Miyaura coupling (BSC) reaction with low catalyst loading (2 mol‐%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step.
Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki–Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201101409 |