Synthesis of Triazole‐Epothilones by Using Cu 2 O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition

Synthesis of Triazole‐Epothilones by Using Cu 2 O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition

We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate the macrocyclic ring and the triazole ring was to apply Cu 2 O nanoparticles (Cu 2 O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were in...

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Veröffentlicht in:European journal of organic chemistry 2012-01, Vol.2012 (3), p.500-508
Hauptverfasser: Duan, Xiyan, Zhang, Yan, Ding, Yahui, Lin, Jianping, Kong, Xianglei, Zhang, Quan, Dong, Changming, Luo, Guoan, Chen, Yue
Format: Artikel
Sprache:eng
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Zusammenfassung:We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate the macrocyclic ring and the triazole ring was to apply Cu 2 O nanoparticles (Cu 2 O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201101306