The Development of Domino Reactions Incorporating the Heck Reaction: The Formation of N-Heterocycles

The methodological development of a series of domino or cascade reactions affording a series of N‐heterocycles is described. The rapid formation of these ring systems is in each case associated with the incorporation of a Heck reaction at either an early or a late stage of the domino process. A range of catalytic conditions and substrate modifications for optimisation of domino Tsuji–Trost/Heck, Buchwald–Hartwig/Heck and Heck/carbopalladation reaction sequences are reported. The development of a series of domino or cascade reactions affording a collection of N‐heterocycles is described. In each of the processes a palladium‐catalysed Heck cross‐coupling reaction in utilised to produce the desired ring system efficiently.